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Pencil drawing of on-skin electronics on papers. Conceptual illustrations of drawing on-skin electronics on papers using a 9B sketching pencil.
One day, people could monitor their own health conditions by simply picking up a pencil and drawing a bioelectronic device on their skin. In a new study, University of Missouri engineers demonstrated that the simple combination of pencils and paper could be used to create devices that might be used to monitor personal health.
Their findings are published in the journal Proceedings of the National Academy of Sciences.
Zheng Yan, an assistant professor in the College of Engineering, said many existing commercial on-skin biomedical devices often contain two major components — a biomedical tracking component and a surrounding flexible material, such as plastic, to provide a supportive structure for the component to maintain an on-skin connection with a person’s body.
EMG recording and water dissolution of bioelectronic sensors based on pencils and water-soluble papers.
“The conventional approach for developing an on-skin biomedical electronic device is usually complex and often expensive to produce,” he said. “In contrast, our approach is low-cost and very simple. We can make a similar device using widely available pencils and paper.”
Since its invention, pencils — made of lead including various levels of graphite, clay and wax — have often been used for writing and drawing. In the study, the researchers discovered that pencils containing more than 90% graphite are able to conduct a high amount of energy created from the friction between paper and pencil caused by drawing or writing. Specifically, the researchers found pencils with 93% graphite were the best for creating a variety of on-skin bioelectronic devices drawn on commercial office copy paper. Yan said a biocompatible spray-on adhesive could also be applied to the paper to help it stick better to a person’s skin.
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Image credit: Jialun Zhu, Shuyu Lin, and Yichao Zhao (I²BL/UCLA)
Engineers at the UCLA Samueli School of Engineering and their colleagues at Stanford School of Medicine have demonstrated that drug levels inside the body can be tracked in real time using a custom smartwatch that analyzes the chemicals found in sweat. This wearable technology could be incorporated into a more personalized approach to medicine — where an ideal drug and dosages can be tailored to an individual.
A study detailing the research was published in Proceedings of the National Academy of Sciences.
In general, medications are prescribed with a ‘one-size-fits-all’ approach — drugs are designed and prescribed based on statistical averages of their effectiveness. There are guidelines for factors such as patients’ weight and age. But in addition to these basic differentiators, our body chemistry constantly changes — depending on what we eat and how much we’ve exercised. And on top of these dynamic factors, every individual’s genetic makeup is unique and hence responses to medications can vary. This affects how fast drugs are absorbed, take effect and get eliminated from an individual.
According to the researchers, current efforts to personalize the drug dosage rely heavily on repeated blood draws at the hospital. The samples are then sent out to be analyzed in central labs. These solutions are inconvenient, time-consuming, invasive and expensive. That is why they are only performed on a small subset of patients and on rare occasions.
“We wanted to create a wearable technology that can track the profile of medication inside the body continuously and non-invasively,” said study leader Sam Emaminejad, an assistant professor of electrical and computer engineering at UCLA. “This way, we can tailor the optimal dosage and timing of the intake for each individual. And using this personalization approach, we can improve the efficacy of the therapeutic treatments.”